A 30 gallon or larger, fish-only aquarium is suitable. It may eat invertebrates found in a reef tank. Its teeth are actually a fused beak-like structure.
Parts of its flesh are poisonous. It has the ability, when threatened or alarmed, to inflate its body to almost twice its normal size. It becomes alarmed when netted, therefore, use a container to transfer it.
The Saddle Valentini Puffer needs a varied diet of meaty foods including; squid, krill, clams, and hard shelled shrimp to help wear down their ever growing teeth.